Free shipping on all orders over $ 500

Recombinant Human uPA (HEK293, C-6His)

Cat. No. M45059

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human uPA (HEK293, C-6His) Structure
Synonym:

Urokinase-Type Plasminogen Activator; U-Plasminogen Activator

Size Price Availability Quantity
10ug USD 275  USD275 In stock
50ug USD 720  USD720 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Human Urokinase-Type Plasminogen Activator is a potent marker of invasion and metastasis in many human cancers associated with breast, colon, stomach, bladder, brain, ovary and endometrium. Urokinase-Type Plasminogen Activator specifically cleaves the zymogen plasminogen to form the active enzyme plasmin.

Recombinant Human Urokinase-Type Plasminogen Activator/uPA expressed the target gene encoding Ser21-Leu431 with a 6His tag at the C-terminus.


Accession: P00749

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 45-55 KDa, reducing conditions

Supplied as a 0.2 μm filtered solution of 20mM HEPES, 2mM CaCl2, 10% Glycerol, pH 7.4.

This product is shipped on dry ice. Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Form Solution
Storage Store at ≤ -70°C, stable for 6 months after receipt.
References

[1] Tao Song, et al. Int J Clin Exp Pathol. The overexpression of uPA promotes the proliferation and fibrinolytic activity of human umbilical vein endothelial cells

[2] Rais Reskiawan A Kadir, et al. Cell Mol Neurobiol. Urokinase Plasminogen Activator: A Potential Thrombolytic Agent for Ischaemic Stroke

[3] Manman Su, et al. Int J Oncol. Expression and anticancer activity analysis of recombinant human uPA1‑43-melittin

[4] Weimin Zhou. Mol Med Rep. Effect of adenovirus‑mediated uPA gene transduction on the fibrinolytic activity of human umbilical vein endothelial cells

[5] O Wilhelm, et al. FEBS Lett. Recombinant soluble urokinase receptor as a scavenger for urokinase-type plasminogen activator (uPA). Inhibition of proliferation and invasion of human ovarian cancer cells

Related Cytokines and Growth Factors Products
Recombinant Human GDF-15 Protein (HEK293 N-hFc)

Growth-differentiation factor 15 (GDF15), also known as MIC-1, is a secreted member of the transforming growth factor (TGF)-β superfamily. GDF-15 has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF-15 overexpression arising from an expanded erythroid compartment contributes to iron overload in thalassemia syndromes by inhibiting hepcidin expression.

Recombinant Human FGFR1 Protein (HEK293, C-His)

FGFR1, also known as CD331, is a full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain.

Recombinant Human FGFR2 Protein (HEK293, C-His)

FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts.

Recombinant Mouse BMP-4 Protein (E. coli, C-His)

Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures.

Recombinant Human Coagulation Factor X (HEK293, C-Fc)

Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.

  Catalog
Abmole Inhibitor Catalog




Keywords: Recombinant Human uPA (HEK293, C-6His), Urokinase-Type Plasminogen Activator; U-Plasminogen Activator supplier, Cytokines and Growth Factors, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.



Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.