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Recombinant Human UBE2V1 (E.coli, C-6His)

Cat. No. M21613
Recombinant Human UBE2V1 (E.coli, C-6His) Structure
Synonym:

Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV-1

Size Price Availability Quantity
10ug USD 150  USD150 In stock
50ug USD 230  USD230 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1.0 EU/µg
  • COA
  • MSDS
Biological Activity

Ubiquitin-Conjugating Enzyme Variant 1a (UBE2V1) plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6, and TRAF2. It mediates transcriptional activation of target genes. UBE2V1 also controls the progress through the cell cycle and differentiation, the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Recombinant Human Ubiquitin-Conjugating Enzyme E2 Variant 1 is produced by E.coli expression system and the target gene encoding Ala2-Asn147 is expressed with a 6His tag at the C-terminus.

Chemical Information
Solubility (25°C) Water
Saline
PBS
Storage Store at ≤ -70°C, stable for 6 months after receipt
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Joanna Liwocha, et al. Nat Chem Biol. Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler

[2] Rebecca J Burge, et al. PLoS Pathog. Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex

[3] Tatsuya Sawasaki, et al. Methods Mol Biol. Cell-free-based protein microarray technology using agarose/DNA microplate

[4] Sachiko Tsukamoto, et al. Bioorg Med Chem Lett. Leucettamol A: a new inhibitor of Ubc13-Uev1A interaction isolated from a marine sponge, Leucetta aff. microrhaphis

[5] M L Rothofsky, et al. Gene. CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter

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Keywords: Recombinant Human UBE2V1 (E.coli, C-6His), Ubiquitin-Conjugating Enzyme E2 Variant 1; UEV-1 supplier, Recombinant Proteins, inhibitors, activators


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