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Tissue-type plasminogen activator (TPA) is a protein that secreted into extracellular space. It belongs to the peptidase S1 family. The main function of this protein is to convert plasminogen into biologically active plasmin.
As a protease, TPA plays a crucial role in regulating blood fibrinolysis, maintaining the homeostasis of extracellular matrix and in modulating the post-translational activation of growth factors. In addition, as a cytokine, TPA plays a pivotal role in the pathogenesis of renal interstitial fibrosis through diverse mechanisms. Thus, as a fibrogenic cytokine, it promotes the progression of kidney diseases.
Recombinant Human Tissue-type Plasminogen Activator (TPA) expressed the target gene encoding Ser36-Pro562 with a 6His tag at the C-terminus.
Accession: P00750
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 55-80 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM Succinate, 4% Trehalose, 4% Mannitol, 0.2mM CaCl2, 0.02% Tween 80, pH 4.5.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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