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Recombinant Human TGF-β2 Protein

Cat. No. M9988
Recombinant Human TGF-β2 Protein Structure
Synonym:

rhTGF-β2; TGF-beta2

Size Price Availability Quantity
10ug USD 480  USD480 In stock
50ug USD 1250  USD1250 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Recombinant Human TGF-β2 Protein is a multifunctional cytokine that regulates cell proliferation, growth, differentiation and movement, as well as the synthesis and deposition of extracellular matrix. The three mammalian subtypes, transforming growth factor-β, transforming growth factor-β1, β2, and β3, send signals through the same receptor, causing similar biological responses. TGF-β2 has an inhibitory effect on IL-2-dependent T cell growth, and may exert an autocrine function through immune surveillance that inhibits tumor growth.

Measured in a cell proliferation assay using mouse HT-2 cells, the ED50 is < 0.2 ng/ml.

Expression host is Human Cells


Accession: P61812

Endotoxin < 1 EU/µg

Apparent Molecular Weight: ~12.7 kDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution in 4 mM HCl.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human TGF-β2 Protein, rhTGF-β2; TGF-beta2 supplier, Recombinant Proteins, inhibitors, activators


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