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Recombinant Human TRAIL/Apo2L Protein is a cytotoxic protein that can activate the rapid apoptosis of tumor cells, but does not work in normal cells. TRAIL-induced apoptosis is achieved by binding to two death signal receptors DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain" that activates the cell's apoptosis mechanism.
Measured by the cell growth inhibitory assay using RPMI-8226 cells, the ED50 is < 40.0 ng/ml, corresponding to a specific activity of > 2.5 × 104 units/mg.
Recombinant Human TRAIL/Apo2L expressed the target gene encoding Val114-Gly281.
Accession: P50591
Endotoxin < 0.2 EU/μg
Apparent Molecular Weight: ~19.6 kDa, reducing conditions
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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