Vaspin (Visceral Adipose-Specific SERPIN) is a newly described adipokine. Vaspin is also a unique insulin sensitizing adipocytokine in obesity. Vaspin has three β-sheets, nine α-helices, and one central loop; the structure is part of the set of distinctive features that are descriptive of Serpin family members. Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat.
Recombinant Human Vaspin/Serpin A12 expressed the target gene encoding Leu21-Lys414 with a GST tag at the N-terminus.
Accession: Q8IW75
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 72 KDa, reducing conditions
Supplied as a 0.2 μm filtered solution of 50mM Tris-HCl, 160mM NaCl, 0.2mM PMSF, 1mM DTT, 10% Glycerine, pH 7.2.
This product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.
| Form | Solution |
| Storage | Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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