Stromal cell-derived factor-1β (SDF-1β), also known as SCYB12, PBSF, and CXCL12, is an 8.3 kDa, heparin-bound member of the CXC(or α) chemokine family that signals via the CXCR4 receptor. SDF-1α and β are reported to be monomers at neutral pH and physiological ionic strength. At the cell surface, this may well facilitate the interaction of SDF-1 with its two receptors, CXCR4 and syndecan4. Heparan sulfate is known to protect SDF-1 from proteolysis, and CXCR4 exists as a dimer component. Among its many functions, CXCL12 is known to affect lymphogenesis, regulate neural progenitor cell patterns and cell numbers, and promote angiogenesis (12,13). It also enhances the survival of myeloid progenitor cells.
The biological activity determined by a chemotaxis bioassay using PHA and rHuIL-2 activated human peripheral blood T-lymphocytes is in a concentration range of 20.0-80.0 ng/ml.
Accession: P48061
Theoretical Molecular Weight: 8.5 kDa
Endotoxin < 1 EU/μg
Lyophilized from a 0.2 μm filtered solution in PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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