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Recombinant Human S100A8 (E.coli, C-6His)

Cat. No. M21410

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human S100A8 (E.coli, C-6His) Structure
Synonym:

Protein S100-A8; S100A8; Calgranulin-A

Size Price Availability Quantity
10ug USD 130  USD130 In stock
50ug USD 270  USD270 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin<1 EU/µg
  • COA
  • MSDS
Biological Activity

S100-A8 (also MRP8 and calgranulin A) is a calcium- and zinc-binding protein. It plays a prominent role in the regulation of inflammatory processes and immune response. S100A8 can induce neutrophil chemotaxis and adhesion. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. It can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Recombinant Human S100A8 expressed the target gene encoding Met1-Glu93 with a 6His tag at the C-terminus.


Accession: P05109

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 13 KDa, reducing conditions

Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 8% Sucrose, 150mM NaCl, 20% Glycerol, 2mM EDTA, 0.05% Tween 80, pH 8.5.

The product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Form Solution
Storage Store at ≤ -70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
References

[1] Ayaka Nakatani, et al. Allergol Int. S100A8 enhances IL-1β production from nasal epithelial cells in eosinophilic chronic rhinosinusitis

[2] Martina Colicchia, et al. Blood. S100A8/A9 drives the formation of procoagulant platelets through GPIbα

[3] Kohei Tanigawa, et al. Am J Pathol. S100A8/A9 Induced by Interaction with Macrophages in Esophageal Squamous Cell Carcinoma Promotes the Migration and Invasion of Cancer Cells via Akt and p38 MAPK Pathways

[4] Lanlan Jiang, et al. J Oral Pathol Med. Recombinant human interleukin 17A enhances the anti-Candida effect of human oral mucosal epithelial cells by inhibiting Candida albicans growth and inducing antimicrobial peptides secretion

[5] Yun-fei Zheng, et al. Beijing Da Xue Xue Bao Yi Xue Ban. [Effect of recombinant human S100A8 on the proliferation and migration of periodontal ligament cells]

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Keywords: Recombinant Human S100A8 (E.coli, C-6His), Protein S100-A8; S100A8; Calgranulin-A supplier, Cytokines and Growth Factors, inhibitors, activators

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