All AbMole products are for research use only, cannot be used for human consumption.
Species: Human
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test measured less than 0.1 ng/µg (1EU/µg)
Molecular weight: 11.7 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months.
Bioactivity: S100A11 is a member of the calcium-binding protein S100 family. Human S100A11 contains two EF hand motifs, 82% of which share the same amino acid sequence as mouse and rat S100A11. It forms a covalent homodimer and a disulfide tetramer under the action of transglutamine. S100A11 is secreted by keratinocytes and can be cross-linked into the keratinocyte envelope of the skin. Dimerization enhances its ability to signal keratinocytes via RAGE, induce EGF family protein production, and induce cell proliferation. Dimerization also causes S100A11 to bind to RAGE on chondrocytes, leading to chondrocyte hypertrophy and catabolism of cartilage matrix. In addition, S100A11 is found in the cytoplasm and is phosphorylated and transferred to the nucleus in response to DNA damage, RELM alpha exposure, or elevated extracellular calcium concentrations. Calcium also promotes the binding of S100A11 to S100B and to annexins A1, A2 and A6. The S100A11-Annexin A2 complexes are recruited to sites of plasma membrane damage where they promote membrane repair of migrating cancer cells. S100A11 is upregulated in various cancers, supporting tumor cell proliferation, invasion and migration. In addition, S100A11 is produced in the ovary and acts on cumulus cells to inhibit oocyte fertilization.
| Solubility (25°C) | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cytokines and Growth Factors Products |
|---|
| Recombinant Human FGF-8b Protein (E. coli)
Recombinant Human FGF-8b Protein is a heparin-binding growth factor, which plays a core role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and other effect. |
| Recombinant Rat GDNF Protein (Baculovirus-Insect, N-His)
GDNF is an important member of the GDNF family of ligands. GDNF plays a key role in the promotion of the survival of dopaminergic neurons. GDNF is a highly conserved neurotrophic factor. The recombinant form of this protein also promotes the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. GDNF also regulates kidney development and spermatogenesis, and it affects alcohol consumption. |
| Recombinant Rat PDGF-BB (E. coli)
Platelet-Derived Growth Factor-BB (PDGF-BB) is one of five dimers (PDGF-AA, AB, BB, CC, and DD) formed by 4 different PDGF subunits. PDGF-BB functions in a paracrine manner and promotes organogenesis, human skeletal development, and wound healing. PDGF-BB also promotes angiogenesis, particularly in the presence of Fibroblast Growth Factor basic. |
| Recombinant Human ApoE3 Protein (HEK293, C-6His)
ApoE is a constituent of a subclass of high density of lipoproteins (HDL) involved in cholesterol transport. ApoE mediates high affinity binding of chylomicrons and vLDL particles to the LDL receptor, allowing for specific uptake of these particles by the liver, preventing the accumulation of cholesterol rich particles in the plasma. |
| Recombinant Mouse Granzyme B (HEK293, C-6His)
Granzyme B (GZMB) is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp and seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. The protein cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
