All AbMole products are for research use only, cannot be used for human consumption.
Species: Human
Expression system: E.coli
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test measured less than 0.1 ng/µg (1EU/µg)
Molecular weight: 11.7 KDa
Storage and stability: The freeze-dried protein should be stored at ≤-20°C for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The bisector of the recombinant sample was stable at ≤-20°C for 3 months.
Bioactivity: S100A11 is a member of the calcium-binding protein S100 family. Human S100A11 contains two EF hand motifs, 82% of which share the same amino acid sequence as mouse and rat S100A11. It forms a covalent homodimer and a disulfide tetramer under the action of transglutamine. S100A11 is secreted by keratinocytes and can be cross-linked into the keratinocyte envelope of the skin. Dimerization enhances its ability to signal keratinocytes via RAGE, induce EGF family protein production, and induce cell proliferation. Dimerization also causes S100A11 to bind to RAGE on chondrocytes, leading to chondrocyte hypertrophy and catabolism of cartilage matrix. In addition, S100A11 is found in the cytoplasm and is phosphorylated and transferred to the nucleus in response to DNA damage, RELM alpha exposure, or elevated extracellular calcium concentrations. Calcium also promotes the binding of S100A11 to S100B and to annexins A1, A2 and A6. The S100A11-Annexin A2 complexes are recruited to sites of plasma membrane damage where they promote membrane repair of migrating cancer cells. S100A11 is upregulated in various cancers, supporting tumor cell proliferation, invasion and migration. In addition, S100A11 is produced in the ovary and acts on cumulus cells to inhibit oocyte fertilization.
Solubility (25°C) | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Related Recombinant Proteins Products |
---|
Recombinant Human HMGB1 Protein (E. coli)
High mobility group protein B1 is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. As a nuclear protein, HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile, it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte, T cell, dendritic cell activities in inflammatory responses. |
Recombinant Human IL-25/IL-17E (E. coli, C-His)
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. |
Recombinant Human IL-25/IL-17E (Mammalian, C-6His)
Interleukin 25 (IL-25) belongs to the Interleukin 17 (IL-17) family of proteins. IL25 is a glycoprotein secreted as dimers by innate effector eosinophils and basophils, and present at very low levels in various peripheral tissues. IL25, together with IL17B, are ligands for the cytokine receptor IL17BR, and the cross-linking induces NF-κB activation and production of the proinflammatory chemokine IL-8, as well as ERK, JNK, and p38 activation. |
Recombinant Human SEMA3A (Mammalian, N-6His-Flag)
Semaphorin 3A (SEMA3A) is a secreted protein which belongs to the semaphorin family. Semaphorin 3A can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. |
Recombinant Human CD143/ACE (E. coli, N-GST)
CD143/ACE Protein is a recombinant human Angiotensin I-converting enzyme (ACE, CD143) which hydrolyzes small peptides such as angiotensin I, bradykinin, substance P, LH-RH and several others and thus plays a key role in blood pressure regulation and vascular remodeling. ACE plays a crucial role in blood pressure regulation, vascular remodeling, and immunity. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.