R-spondin-3 (RSPO3) is a member of the thrombospondin type 1 repeat supergene family. RSPO3 founctions as a activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Recombinant Human R-Spondin 3 is produced by Mammalian expression system and the target gene encoding Gln22-Val146 is expressed with a 6His tag at the C-terminus.
Accession: Q9BXY4
APMol Mass: 15-25 kDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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