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Recombinant Human PRCP (HEK293, C-6His)

Cat. No. M19977

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human PRCP (HEK293, C-6His) Structure
Synonym:

Lysosomal Pro-X Carboxypeptidase; Angiotensinase C

Size Price Availability Quantity
10ug USD 260  USD260 In stock
50ug USD 700  USD700 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Lysosomal Pro-X carboxypeptidase (PRCP) belongs to peptidase S28 family. PRCP has been detected in many tissues, with the highest levels in placenta, lung, and liver. It is also found in the heart, brain, pancreas and kidneys. PRCP exists as a homodimer. PRCP cleats C-terminal amino acids linked to proline in peptides such as angiotensin II, III, and DES-Arg9-bradykinin. This cleavage occurs at acidic pH, but some substrates remain enzymatic active at neutral pH. PRCP has been shown to be an activator of cell-matrix associated prekallikrein.

Recombinant Human Lysosomal Pro-X Carboxypeptidase expressed the target gene encoding Leu22-His496 with a 6His tag at the C-terminus.


Supplied as a 0.2 μm filtered solution of 20mM NaAc-HAc, 150mM NaCl, 10% Glycerol, pH4.5.

The product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.

Chemical Information
Form Solution
Storage Store at ≤-70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles.
References

[1] J Wang, et al. Curr Mol Med. Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor)

[2] F M Rabey, et al. Curr Med Chem. Influence of a novel inhibitor (UM8190) of prolylcarboxypeptidase (PRCP) on appetite and thrombosis

[3] S M Chajkowski, et al. Biochem Biophys Res Commun. Highly selective hydrolysis of kinins by recombinant prolylcarboxypeptidase

[4] Z Shariat-Madar, et al. Am J Physiol Heart Circ Physiol. Overexpression of prolylcarboxypeptidase enhances plasma prekallikrein activation on Chinese hamster ovary cells

[5] Zia Shariat-Madar, et al. Blood. Recombinant prolylcarboxypeptidase activates plasma prekallikrein

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Keywords: Recombinant Human PRCP (HEK293, C-6His), Lysosomal Pro-X Carboxypeptidase; Angiotensinase C supplier, Cytokines and Growth Factors, inhibitors, activators

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