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Recombinant Human PF-4/CXCL4 Protein (HEK293)

Cat. No. M40706

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human PF-4/CXCL4 Protein (HEK293) Structure
Synonym:

Platelet factor 4; SCYB4

Size Price Availability Quantity
10ug USD 180  USD180 In stock
50ug USD 360  USD360 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Platelet factor 4 (PF-4/CXCL4) is expressed in megakaryocytes and stored in the α-granules of platelets. Recombinant human PF-4 can be proinflammatory and proatherogenic through multiple effects on monocytes, macrophages and endothelial cells.

Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Measured by the ability to inhibit human FGF-basic-dependent proliferation of NR6R 3T3 mouse fibroblast cells, the ED50 is < 10.0 ug/ml.


Accession: P02776

Apparent Molecular Weight: ~7.8 kDa

Endotoxin < 0.2 EU/μg

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C.
References

[1] Katrien Van Raemdonck et al. Angiogenesis. CXCL4L1 and CXCL4 signaling in human lymphatic and microvascular endothelial cells and activated lymphocytes: involvement of mitogen-activated protein (MAP) kinases, Src and p70S6 kinase

[2] Katerina Pilatova et al. J Hematol Oncol. Role of platelet chemokines, PF-4 and CTAP-III, in cancer biology

[3] Sofie Struyf et al. Cancer Res. Platelet factor-4 variant chemokine CXCL4L1 inhibits melanoma and lung carcinoma growth and metastasis by preventing angiogenesis

[4] Laura Lasagni et al. Blood. PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion

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Keywords: Recombinant Human PF-4/CXCL4 Protein (HEK293), Platelet factor 4; SCYB4 supplier, Cytokines and Growth Factors, inhibitors, activators

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