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Recombinant Human PDGF-AA Protein (HEK293)

Cat. No. M9987
Recombinant Human PDGF-AA Protein (HEK293) Structure
Synonym:

rhPDGF-AA

Size Price Availability Quantity
50ug USD 580  USD580 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
Biological Activity

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.

Recombinant human PDGF-AA contains 358 amino acids and the predicted theoretical molecular weight is 41.2kd.

Determined by stimulating the absorption of adenosine by BALB/C 3T3 cells in a dose-dependent manner, the ED50 value is ≤2 ng/mL.

Endotoxin <0.1EU/μg

Product Citations
Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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