PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.
Recombinant human PDGF-AA contains 358 amino acids and the predicted theoretical molecular weight is 41.2kd.
Determined by stimulating the absorption of adenosine by BALB/C 3T3 cells in a dose-dependent manner, the ED50 value is ≤2 ng/mL.
ACS Nano. 2023 Jul 6.
Programming Affinity for Precise Tumor Recognition with Allosteric Nanosensing-Circles
Recombinant Human PDGF-AA Protein (HEK293) purchased from AbMole
|Solubility (25°C)||Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.|
|Storage||Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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