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Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.
Accession: # Q9NZQ7-1
Apparent Molecular Weight: 31~35 kDa, on SDS-PAGE under reducing conditions.
Immobilized PD-L1, His, Human at 2.0 μg/ml (100 μl/well) can bind PD-1, Human.
Lyophilized from a 0.2 μm filtered solution in PBS, 5% trehalose and mannitol.
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml |
| Storage | Stable for up to 6 months at lower than -70°C |
[2] Qingqing Xiao, et al. Acta Pharm Sin B. Biological drug and drug delivery-mediated immunotherapy
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