Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test, less than 0.1 ng/ug (1 EU/ug)
Storage and stability: Storage temperature ≤-70℃, stable storage for 6 months after receiving goods. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.
Bioactivity: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory Subtilisin belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble enzyme that undergoes autocatalytic intramolecular processing during co-secretion of the ER, prodomain, and mature chain through noncovalent interactions. PCSK9 binds to the low-density lipoprotein receptor (LDLR) and plays an important regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a way to reduce cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) and plays a role in neural development.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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