All AbMole products are for research use only, cannot be used for human consumption.
Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory Subtilisin belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble enzyme that undergoes autocatalytic intramolecular processing during co-secretion of the ER, prodomain, and mature chain through noncovalent interactions. PCSK9 binds to the low-density lipoprotein receptor (LDLR) and plays an important regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a way to reduce cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) and plays a role in neural development.
Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9 expressed target gene encoding Gln31-Gln692 (Val474Ile, Gly670Glu) with a 6His tag at the C-terminus.
Supplied as a 0.2 μm filtered solution of 20mM NaH2PO4, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 0.01% Tween20, pH 7.4.
The product is shipped on dry ice packs. Upon receipt, store it immediately at the temperature listed below.
| Form | Solution |
| Storage | Store at ≤-70°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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