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Recombinant Human PCSK9 (Mammalian,C-6His)

Cat. No. M15098
Recombinant Human PCSK9 (Mammalian,C-6His) Structure
Synonym:

Proprotein Convertase Subtilisin/Kexin Type 9

Size Price Availability Quantity
10ug USD 250  USD250 In stock
50ug USD 500  USD500 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/ug
  • COA
  • MSDS
Biological Activity

Species: Human
Expression system: Mammalian
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test, less than 0.1 ng/ug (1 EU/ug)
Storage and stability: Storage temperature ≤-70℃, stable storage for 6 months after receiving goods. After opening, store in aseptic condition for 3 months, storage temperature ≤-70℃. Please minimize freeze-thaw cycles.

Bioactivity: Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory Subtilisin belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble enzyme that undergoes autocatalytic intramolecular processing during co-secretion of the ER, prodomain, and mature chain through noncovalent interactions. PCSK9 binds to the low-density lipoprotein receptor (LDLR) and plays an important regulatory role in cholesterol homeostasis. Inhibition of PCSK9 function by preventing PCSK9/LDLR interaction is currently being explored as a way to reduce cholesterol levels. PCSK9 also binds to apolipoprotein receptor 2 (ApoER2) and plays a role in neural development.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/ug
Solubility N/A
Storage at -20°C
References

[1] Brian H Annex, et al. Circ Res. New Directions in Therapeutic Angiogenesis and Arteriogenesis in Peripheral Arterial Disease

[2] Tomš Krl. Vnitr Lek. Praluent (alirokumab)

[3] Jean-Louis Vincent, et al. JAMA. Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial

[4] Zufeng Ding, et al. Cardiovasc Res. PCSK9 expression in the ischaemic heart and its relationship to infarct size, cardiac function, and development of autophagy

[5] Annie Demers, et al. Arterioscler Thromb Vasc Biol. PCSK9 Induces CD36 Degradation and Affects Long-Chain Fatty Acid Uptake and Triglyceride Metabolism in Adipocytes and in Mouse Liver

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Keywords: Recombinant Human PCSK9 (Mammalian,C-6His), Proprotein Convertase Subtilisin/Kexin Type 9 supplier, Cytokines, inhibitors

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