Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1 or OLR1), also known as LOX1, is a receptor protein that belongs to the C-type lectin superfamily. LOX1 may play an important role in the progression of vulnerable carotid plaque and might regulate vulnerable plaque formation in cooperation with MMPs and TIMP-2. Ox-LDL receptor 1 is expressed at high levels in endothelial cells and vascular rich organs such as placenta, lung, liver, brain, intima of the aorta, bone marrow, spinal cord and substantia nigra. Ox-LDL receptor 1 expression is induced by inflammatory cytokines such as TNF, IFNG, and IL6 in the context of hyperlipidemia, hypertension, and diabetes. Ox-LDL receptor-1 mediates the recognition, internalization, and degradation of oxidation-modified low-density lipoproteins (OxLDL) by vascular endothelial cells.
Recombinant Human OLR1/LOX1 expressed the target gene encoding Ser61-Gln273 with a 6His tag at the C-terminus.
Accession: P78380
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 30-35 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Bertram Pitt. Circulation. A new HOPE for aldosterone blockade?
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