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Recombinant Human NRG2 Protein (HEK293, C-His)

Cat. No. M31146

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human NRG2 Protein (HEK293, C-His) Structure
Synonym:

Neuregulin-2

Size Price Availability Quantity
100ug USD 980  USD980 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Neuregulin-2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. NRG2 plays a key role in nitrate regulation in part through modulating NRT1.1 expression and may function with NLP7 via their physical interaction.

Through interaction with the ErbB family of receptors, neuregulin-2 induces the growth and differentiation of epithelial, neuronal, glial and other types of cells. A mutation in NRG2 disrupted the induction of nitrate-responsive genes after nitrate treatment by an ammonium-independent mechanism.

The recombinant human NRG2 consists of 304 amino acids and predicts a molecular mass of 34 kDa.


Endotoxin < 1.0 EU/μg

Lyophilized from sterile PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml.
Storage Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Misako Nagasaka, et al. Trends Cancer. NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis

[2] W Zhao, et al. Nan Fang Yi Ke Da Xue Xue Bao. [Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling]

[3] Christelle Carteron, et al. J Cell Sci. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival

[4] Beatrice Mautino, et al. Protein Expr Purif. Bioactive recombinant neuregulin-1, -2, and -3 expressed in Escherichia coli

[5] Y Y Zhao, et al. Circ Res. Neuregulin signaling in the heart. Dynamic targeting of erbB4 to caveolar microdomains in cardiac myocytes

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Keywords: Recombinant Human NRG2 Protein (HEK293, C-His), Neuregulin-2 supplier, Cytokines and Growth Factors, inhibitors, activators

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