All AbMole products are for research use only, cannot be used for human consumption.
Species: Human
Expression system: E.coli
Purity: greater than 85% determined by reducing SDS-page
Endotoxin: less than 0.001 ng/ug (0.01 EU/ug) as determined by LAL
Storage and stability: Lyophilized proteins should be stored at < -20°C but can be stored at room temperature for up to 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The isometric solution of the recombinant sample was stable at < -20°C for 3 months.
Biological activity: NRG1 (pro-neuregulin-1, Neuregulin-1 beta 1) is a single-pathway type I membrane protein belonging to the Neuregulin family, which contains an EGF-like domain and an IG-LIKE C2 (immunoglobulin like) domain. The direct ligand of ERBB3 and ERBB4 tyrosine kinase receptors. This protein recruits both ERBB1 and ERBB2 co-receptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of ERBB receptors. Multiple subtypes have multiple functions, such as inducing the growth and differentiation of epithelial cells, glial cells, neuronal cells and skeletal muscle cells; The expression of acetylcholine receptors in synaptic vesicles during the formation of neuromuscular junctions stimulates alveolar budding and lactation induces differentiation of breast tumor cells and stimulates proliferation of Schwann cells. Associated with cardiac muscle development, such as trabecular formation of the developing heart. Isoform 10 May play a role in the development of motor and sensory neurons.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100 μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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