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Recombinant Human Noggin Protein

Cat. No. M9999
Recombinant Human Noggin Protein Structure
Synonym:

rhNoggin GMP

Size Price Availability Quantity
10ug USD 144  USD160 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human Noggin Protein can bind to ligands of the transforming growth factor-β family and regulate its activity by inhibiting its pathway with signal receptors. Noggin was initially identified as a BMP-4 antagonist, and its effect is essential for the normal formation of the head and other back structures. Therefore, noggin has been shown to regulate the activities of other BMP-2, -7, -13 and -14. Transgenic mice overexpress noggin in mature osteoblasts, which is manifested by impaired differentiation of osteoblasts, decreased bone formation, and severe osteoporosis. 

Determined by the ability of ATDC chondrocytes to inhibit the production of alkaline phosphatase by 5.0 ng/ml BMP-4, the expected ED50 of this effect is about 2.0-3.0 ng/ml concentration of Noggin. 

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.01EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
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