Brain-derived Neurotrophic Factor (BDNF) is a member of the Neurotrophic Factor family. Together with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with TrkB kinase receptors with high affinity. It also binds to LNGFR(low affinity nerve growth factor receptor, also known as P75). BDNF promotes the survival, growth and differentiation of neurons. It plays an important role in synaptic transmission and plasticity regulation in adult synapses in many regions of the central nervous system. BDNF expression is altered in neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease.
The ED50 of Human BDNF is 47.58 ng/ml.
Accession: P23560
APMol Mass: 14 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.2.
| Form | Lyophilized powder |
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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