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Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His)

Cat. No. M21205
Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His) Structure
Synonym:

Fibronectin type III domain-containing protein 5

Size Price Availability Quantity
10ug USD 148  USD185 In stock
50ug USD 360  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: human/mouse/rat
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 13.4 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable for 3 months at <-20°C.

Bioactivity: Protein 5 containing the fibronectin type III structural domain, a precursor of irisin, is a protein encoded by the FNDC5 gene. Human irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with 121 extracellular structural domains (ECDs), 21 transmembrane structural domains and 39 cytoplasmic structural domains. the ECD of Irisin contains a fibronectin type III structural domain and multiple glycosylation sites. irisin induces peroxisome proliferator-activated receptor γ Irisin also regulates neuronal differentiation and neuronal growth in the brain and is involved in the differentiation of osteoblasts.







Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/µg
Solubility It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
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Keywords: Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His), Fibronectin type III domain-containing protein 5 supplier, Cytokines, inhibitors

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