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Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His)

Cat. No. M21205
Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His) Structure

Fibronectin type III domain-containing protein 5

Size Price Availability Quantity
10ug USD 185  USD185 In stock
50ug USD 450  USD450 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Species: human/mouse/rat
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 13.4 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable for 3 months at <-20°C.

Bioactivity: Protein 5 containing the fibronectin type III structural domain, a precursor of irisin, is a protein encoded by the FNDC5 gene. Human irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with 121 extracellular structural domains (ECDs), 21 transmembrane structural domains and 39 cytoplasmic structural domains. the ECD of Irisin contains a fibronectin type III structural domain and multiple glycosylation sites. irisin induces peroxisome proliferator-activated receptor γ Irisin also regulates neuronal differentiation and neuronal growth in the brain and is involved in the differentiation of osteoblasts.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human/Mouse/Rat Irisin (Mammalian, N-6His), Fibronectin type III domain-containing protein 5 supplier, Cytokines, inhibitors, activators

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