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Species: human/mouse/rat
Expression system: Mammalian
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Molecular weight: 39.7 KDa
Storage and Stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable for 3 months at <-20°C.
Bioactivity: Protein 5 containing the fibronectin type III structural domain, a precursor of irisin, is a protein encoded by the FNDC5 gene. Human irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with 121 extracellular structural domains (ECDs), 21 transmembrane structural domains and 39 cytoplasmic structural domains. the ECD of Irisin contains a fibronectin type III structural domain and multiple glycosylation sites. irisin induces peroxisome proliferator-activated receptor γ Irisin also regulates neuronal differentiation and neuronal growth in the brain and is involved in the differentiation of osteoblasts.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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