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Recombinant Human KGF/FGF-7 Protein (HEK293)

Cat. No. M10004
Recombinant Human KGF/FGF-7 Protein (HEK293) Structure
Synonym:

HBGF-7

Size Price Availability Quantity
10ug USD 200  USD200 In stock
20ug USD 300  USD300 In stock
100ug USD 1200  USD1200 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human KGF/FGF-7 Protein (HEK293) is a mitogenic factor specific to epithelial cells and keratinocytes, it plays an important role in the development of kidney and lung, as well as angiogenesis and wound healing.

Determined by dose-dependently stimulating the uptake of thymine by KGF-sensitive BaF 3 cells, its expected ED50 value is ≤20 ng/ml.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤-20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Janet M Trowbridge, et al. J Biol Chem. Dermatan sulfate binds and potentiates activity of keratinocyte growth factor (FGF-7)

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Keywords: Recombinant Human KGF/FGF-7 Protein (HEK293), HBGF-7 supplier, Recombinant Proteins, inhibitors, activators


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