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Recombinant Human KGF (E.coli)

Cat. No. M15069
Recombinant Human KGF (E.coli) Structure
Synonym:

Fibroblast growth factor 7; FGF-7

Size Price Availability Quantity
10ug USD 255  USD255 In stock
50ug USD 700  USD700 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human KGF (FGF7) is a secreted protein mainly located in epithelial cells and belongs to the heparin binding growth factor family. FGF family members have a wide range of mitosis and cell survival activities and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a powerful epithelial cell-specific growth factor with mitotic activity mainly in keratinocytes rather than fibroblasts and endothelial cells. This may be the main paracrine effect of normal epithelial cell proliferation.


Expression system: E.coli

Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin < 1 EU/ug

Lyophilized from a 0.2 μm filtered solution of 20mM Tris,1mM EDTA,5% Trehalose, 0.02% Tween 80, pH 8.0.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Young Su Kim, et al. Microb Cell Fact. Effective production of human growth factors in Escherichia coli by fusing with small protein 6HFh8

[2] Mansoureh Shahbazi Dastjerdeh, et al. Comput Biol Chem. In silico analysis of different signal peptides for the secretory production of recombinant human keratinocyte growth factor in Escherichia coli

[3] Jason C Gardner, et al. Am J Physiol Lung Cell Mol Physiol. Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function

[4] Xiaoping Wu, et al. Appl Microbiol Biotechnol. Large-scale production of biologically active human keratinocyte growth factor-2

[5] Jun-Hyeog Jang. Biotechnol Lett. Stimulation of human hair growth by the recombinant human keratinocyte growth factor-2 (KGF-2)

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Keywords: Recombinant Human KGF (E.coli), Fibroblast growth factor 7; FGF-7 supplier, Recombinant Proteins, inhibitors, activators


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