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Recombinant Human IL18R1 (HEK293, C-6His)

Cat. No. M40608

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human IL18R1 (HEK293, C-6His) Structure
Synonym:

Interleukin-18 receptor 1; IL-18R-alpha

Size Price Availability Quantity
10ug USD 105  USD105 In stock
50ug USD 220  USD220 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

The interleukin 18 receptor 1 (IL18R1) belongs to interleukin 1 receptor family. IL18R1 has been shown to mediate EAE through regulation of both IL-18-dependent and -independent pathways. Reaserches show that the increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target.

Recombinant Human Interleukin-18 Receptor 1 expressed the target gene encoding Ala19-Arg329 and with a 6His tag at the C-terminus.


Accession: Q13478

Apparent Molecular Weight: 50-75 KDa, reducing conditions

Endotoxin < 1 EU/µg

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at ≤ -20°C for 3 months.
References

[1] Irene Tsilioni et al. Proc Natl Acad Sci U S A. IL-37 is increased in brains of children with autism spectrum disorder and inhibits human microglia stimulated by neurotensin

[2] Athip Nilkaeo et al. Mediators Inflamm. Role of interleukin-18 in modulation of oral carcinoma cell proliferation

[3] H Tsutsui et al. Immunol Rev. Pathophysiological roles of interleukin-18 in inflammatory liver diseases

[4] M T Gillespie et al. Cytokine Growth Factor Rev. Interleukin-18: perspectives on the newest interleukin

[5] K Kohno et al. Clin Immunol Immunopathol. Interleukin 18, a cytokine which resembles IL-1 structurally and IL-12 functionally but exerts its effect independently of both

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Keywords: Recombinant Human IL18R1 (HEK293, C-6His), Interleukin-18 receptor 1; IL-18R-alpha supplier, Cytokines and Growth Factors, inhibitors, activators

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