Interleukin-6 receptor α, also known as IL-6RA, IL-6R1 and CD126, is a member of the type I cytokine receptor family. Mainly expressed in T cells, fibroblasts and macrophages. Il-6ra is coupled with GP130 to form IL-6 receptor. Il-6ra binds specifically to IL-6 and depends on GP130 for signaling. Il-6ra dysfunction is associated with the pathogenesis of multiple myeloma, autoimmune diseases, prostate cancer and other diseases. Soluble IL-6RA, composed only of the extracellular domain of IL-6RA, acts as an agonist of IL-6 activity.
Measured in a cell proliferation assay using M1 cells in the presence of 10.0 ng/ mL human IL-6, the ED50 is < 0.2 μg/mL.
Accession: P08887
Apparent Molecular Weight: 54~56 kDa, reducing conditions
Expression System: CHO
Endotoxin < 0.2 EU/μg
Lyophilized after extensive dialysis against PBS.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml. |
| Storage | Stable for up to 6 months at ≤ -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Martin Sheppard, et al. Hum Vaccin Immunother. Tocilizumab (Actemra)
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