Recombinant Human IL-36RA Protein (originally named IL-1F5) can antagonize IL-36α, β or γ-induced NF-RrpB signaling by binding to IL-1Rrp2 receptor, thereby preventing the initiation of functional signals. The IL-1 family consists of 11 structurally related ligands, including the newly renamed IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ( IL-1F9). The interaction of IL-36 ligand and IL-1Rrp2 receptor (IL-1R6) can induce the maturation and activation of dendritic cells.
| Form | Lyophilized powder |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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The recombinant human IL1F9 consists of 168 amino acids and predicts a molecular mass of 19.1 KDa. A DNA sequence encoding the mature form of human IL1F9 (Ser18-Asp169) was expressed with a polyhistide tag at the N-terminus. |
| Recombinant Human IL-36 gamma/IL-1 F9 Protein (E. coli)
The recombinant human IL1F9 consisting of 169 amino acids and has a calculated molecular mass of 18.9 kDa. A DNA sequence encoding the human IL-1F9 isoform 1 (Met 1-Asp 169) was expressed. |
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The Recombinant Dengue virus (type 2, strain New Guinea C) NS1 consists of 371 amino acids and predicts a molecular mass of 42.3 kDa. A DNA sequence encoding the Dengue virus (type 2, strain New Guinea C) NS1 (Asp1-Ala352) was expressed with a polyhistidine tag at the N-terminus. |
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