All AbMole products are for research use only, cannot be used for human consumption.
Recombinant Human IL-36RA Protein (originally named IL-1F5) can antagonize IL-36α, β or γ-induced NF-RrpB signaling by binding to IL-1Rrp2 receptor, thereby preventing the initiation of functional signals. The IL-1 family consists of 11 structurally related ligands, including the newly renamed IL-36RA (IL-1F5), IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ( IL-1F9). The interaction of IL-36 ligand and IL-1Rrp2 receptor (IL-1R6) can induce the maturation and activation of dendritic cells.
Recombinant Human Interleukin-36 Receptor Antagonist Protein expressed the target gene encoding Val2-Asp155.
Measured by its ability to inhibit IL-36 alpha, IL-36 beta or IL-36 gamma-induced IL-8 secretion in A431 human epithelial carcinoma cells, the ED50 for this effect is 23.14 ng/ml.
Accession: Q9UBH0
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 17 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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