Recombinant Human IL-22 Protein (Interleukin-22) is produced by T lymphocytes, inhibits Th2 cells from producing IL-4, and induces acute reactants in the liver and pancreas. IL-22 is a member of the IL-10 regulatory cytokine family, including IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family have partial homology in their amino acid sequences, but they are different in biological function. IL-22 signal is transmitted through a receptor system composed of IL-10Rβ/CRF 2-4 and IL-22R, both of which are members of the class II cytokine receptor family.
The recombinant human IL-22 protein contains 152 amino acids and the predicted molecular weight is 17.6kd.
IL-22's biological activity depends on its ability to activate STAT in receptor ligand interactions. Its ability to induce the secretion of IL-10 colon cancer cells as an indicator of the expected ED50. This effect is 0.7 ~ 1.0 ng/mL.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Purity||≥95%, Endotoxin <0.1EU/ug|
|Storage||2-8°C, dry, sealed|
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