Free shipping on all orders over $ 500

Recombinant Human IL-22 Protein

Cat. No. M9984
Recombinant Human IL-22 Protein Structure
Synonym:

Interleukin-22; rhIL-22

Size Price Availability Quantity
100ug USD 608.4  USD676 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin <0.1EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human IL-22 Protein (Interleukin-22) is produced by T lymphocytes, inhibits Th2 cells from producing IL-4, and induces acute reactants in the liver and pancreas. IL-22 is a member of the IL-10 regulatory cytokine family, including IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family have partial homology in their amino acid sequences, but they are different in biological function. IL-22 signal is transmitted through a receptor system composed of IL-10Rβ/CRF 2-4 and IL-22R, both of which are members of the class II cytokine receptor family. 

The recombinant human IL-22 protein contains 152 amino acids and the predicted molecular weight is 17.6kd. 

IL-22's biological activity depends on its ability to activate STAT in receptor ligand interactions. Its ability to induce the secretion of IL-10 colon cancer cells as an indicator of the expected ED50. This effect is 0.7 ~ 1.0 ng/mL.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin <0.1EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
Related Cytokines Products
Recombinant Human TGF-α (E. coli)

Recombinant Human TGF-α, also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells.

Recombinant Human EGF (E. coli)

Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells.

Recombinant Human FGF-10/KGF-2 (E. coli)

Recombinant Human Fibroblast Growth Factor-10 (FGF-10) is a mitogen mainly produced by mesenchymal stem cells in the lung. FGF-10 belongs to the heparin binding FGF family, and is also known as Keratinocyte Growth Factor-2 (KGF-2). It shares homology with KGF and receptor binding to FGFR2-IIIb.

Recombinant Human HGF (CHO-expressed)

Recombinant human Hepatocyte Growth Factor (rhHGF) , also known as hepatopoietin-A and scatter factor, is a pleiotropic mitogen belonging to the peptidase S1 family (plasminogen subfamily). It is produced by mesenchymal cells and acts on epithelial cells, endothelial cells and haemopoietic progenitor cells.

Recombinant Human Glial Cell Line-derived Neurotrophic Factor

Glial cell-derived neurotrophic factor is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Human IL-22 Protein, Interleukin-22; rhIL-22 supplier, Cytokines, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.