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Recombinant Human IL-22 Protein (HEK293)

Cat. No. M40957

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human IL-22 Protein (HEK293) Structure
Synonym:

Interleukin-22

Size Price Availability Quantity
10ug USD 200  USD200 In stock
50ug USD 650  USD650 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Interleukin-22(IL-22) belongs to a group of cytokines called the IL-10 family or IL-10 superfamily. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens in epithelial cells such as those in the lung and gut. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.

Recombinant Human IL-22 expressed the target gene encoding Ala34-Ile179.

Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells), the ED50 for this effect is less than 0.3 ng/ml.


Accession # Q9GZX6

Endotoxin < 0.2 EU/µg

Apparent Molecular Weight: 16~28 kDa

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Ziye Qu et al. Arthritis Res Ther. IL-22 inhibits bleomycin-induced pulmonary fibrosis in association with inhibition of IL-17A in mice

[2] Wei Chen et al. Clin Transl Med. IL-22-mediated renal metabolic reprogramming via PFKFB3 to treat kidney injury

[3] Tomasz J Guzik et al. Cardiovasc Res. COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options

[4] Zhen Wang et al. Autophagy. Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

[5] Caroline A Lindemans et al. Nature. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration

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Keywords: Recombinant Human IL-22 Protein (HEK293), Interleukin-22 supplier, Cytokines and Growth Factors, inhibitors, activators

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