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Recombinant Human IL-17B (Mammalian, C-Fc)

Cat. No. M45121
Recombinant Human IL-17B (Mammalian, C-Fc) Structure
Synonym:

interleukin-17 beta

Size Price Availability
10ug USD 180  USD180 1-2 Weeks
50ug USD 440  USD440 1-2 Weeks
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. IL-17B binds to Interleukine-17 receptor B (IL-17 RB) and induces the production of inflammatory cytokines and the infiltration of inflammatory immune cells.

Recombinant Human Interleukin-17B expressed the target gene encoding Gln21-Phe180 with a human IgG1 Fc tag at the C-terminus.


Accession: Q9UHF5

Endotoxin < 1 EU/µg

Apparent Molecular Weight: 48 KDa, reducing conditions

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human IL-17B (Mammalian, C-Fc), interleukin-17 beta supplier, Recombinant Proteins, inhibitors, activators


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