Recombinant Human IL-11 Protein (HEK293) is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. IL-11 is expressed in a variety of tissues, including the thymus, lung, bone, connective tissue, and central nervous system. IL-11 plays an important regulatory role in the hematopoiesis process by stimulating the growth of bone marrow, red blood cells and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits the production of pro-inflammatory cytokines, and prevents gastric mucosal damage.
Life Sci. 2023 Jul 24;330:121974.
The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis
Recombinant Human IL-11 Protein (HEK293) purchased from AbMole
Solubility (25°C) | Water Saline PBS |
Storage | 2-8°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
Related Recombinant Proteins Products |
---|
Recombinant Human ANXA2 Protein (E. coli)
Annexin A2 (ANXA2) is a member of the annexin family and has roles in the regulation of cellular growth and in signal transduction pathways. |
Recombinant Human IL-17B (Mammalian, C-Fc)
Interleukin-17B (IL-17B) is a member of IL-17 cytokines family that plays important roles in host defence responses and inflammatory diseases. |
Recombinant Human GOLM1 Protein(C-6His)
Golgi Membrane Protein 1 (GOLM1) belongs to the GOLM1/CASC4 family, GOLM1 is a single-pass type II membrane protein and can be found in many tissues . GOLM1 is overexpressed in prostate cancer and lung adenocarcinoma tissue. GOLM1 can be up-regulated in response to viral infection. GOLM1 is induced by the E1A adenoviral protein. GOLM1 plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. |
Recombinant Mouse Apolipoprotein E (Mammalian, C-6His)
Apolipoprotein E (Apo-E) is a member of the apolipoprotein A1/A4/E family. APOE may function in mediating the binding, internalization, and catabolism of lipoprotein particles. |
Recombinant Human Granzyme B Protein (HEK293, C-His)
Granzyme B is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.