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Recombinant Human IL-11 Protein (HEK293)

Cat. No. M9981
Recombinant Human IL-11 Protein (HEK293) Structure
Size Price Availability Quantity
50ug USD 700  USD700 In stock
100ug USD 1130  USD1130 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin ≤0.02EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human IL-11 Protein (HEK293) is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. IL-11 is expressed in a variety of tissues, including the thymus, lung, bone, connective tissue, and central nervous system. IL-11 plays an important regulatory role in the hematopoiesis process by stimulating the growth of bone marrow, red blood cells and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits the production of pro-inflammatory cytokines, and prevents gastric mucosal damage.

Product Citations
Chemical Information
Solubility (25°C) Water
Saline
PBS
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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