Recombinant Human IL-11 Protein (HEK293) is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. IL-11 is expressed in a variety of tissues, including the thymus, lung, bone, connective tissue, and central nervous system. IL-11 plays an important regulatory role in the hematopoiesis process by stimulating the growth of bone marrow, red blood cells and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits the production of pro-inflammatory cytokines, and prevents gastric mucosal damage.
Life Sci. 2023 Jul 24;330:121974.
The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis
Recombinant Human IL-11 Protein (HEK293) purchased from AbMole
|Storage||2-8°C, dry, sealed|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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