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Recombinant Human IGF-I (E.coli, 67AA)

Cat. No. M21631

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Recombinant Human IGF-I (E.coli, 67AA) Structure
Synonym:

Insulin-Like Growth Factor I; IGF1; Mecasermin

Size Price Availability Quantity
10ug USD 95  USD95 In stock
50ug USD 125  USD125 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.5 EU/μg
  • COA
  • MSDS
Biological Activity

Insulin-like growth factor I (IGF1) binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions.

Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cells. The ED50 for this effect is 20-100 ng/ml.

Chemical Information
Molecular Weight 7645.68
Formula C331H512N94O101S7
CAS Number 68562-41-4
Solubility (25°C) Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml
Storage Stored at ≤ -20°C, stable for one year after receipt
References

[1] Philippe Backeljauw. Growth Horm IGF Res. Therapy with recombinant human IGF-1 for children with primary insulin-like growth factor-I deficiency

[2] Adda Grimberg, et al. Horm Res Paediatr. Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency

[3] George M Bright. Growth Horm IGF Res. Recombinant IGF-I: Past, present and future

[4] Kevin C J Yuen, et al. Growth Horm IGF Res. Impact of treatment with recombinant human GH and IGF-I on visceral adipose tissue and glucose homeostasis in adults

[5] Ross G Clark. Horm Res. Recombinant human insulin-like growth factor I (IGF-I): risks and benefits of normalizing blood IGF-I concentrations

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Keywords: Recombinant Human IGF-I (E.coli, 67AA), Insulin-Like Growth Factor I; IGF1; Mecasermin supplier, Cytokines and Growth Factors, inhibitors, activators

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