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Interferon Alpha/Beta Receptor 1 (IFNAR1) interacts very weakly or not at all with type 1 interferons and does not stably interact with IFN-α/β R2. Ligands associate with IFN-α/β R2, and this complex subsequently forms a stable ternary assembly with IFN-α/β R1. IFN-α/β R1 also associates with IFN-γ R2 even in the absence of IFN-γ stimulation. Human IFN-α/β R1 contains a nuclear localization signal in its extracellular domain that is required for receptor translocation to the nucleus following interaction with ligand. Interferon stimulation results in an immunologic response that is especially associated with viruses. The Interferon-α/β Receptor 1 (IFN-α/β R1) is a receptor which binds Type I Interferons including Interferon-α and -β.
Recombinant Human IFNAR1 expressed the target gene encoding Lys28-Lys436 with a 6His tag at the C-terminus.
Accession: P17181
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 70-120 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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