Recombinant Human IFN-ω Protein signals through the IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. Human IFN-ω is produced by virally induced leukocytes and have similar antiviral activities on human cell lines, IFN-ω exhibits about 75% sequence homology with IFN-α, and contains two conserved disulfide bonds that are necessary for full biological activity. In addition, it was reported that IFN-ω could inhibit the growth of human tumors in vivo.
Expression host is HEK293 cells
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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