Expression system: E.coli
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Apparent molecular weight: 16 KDa, reduced conditions
Storage and stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.
Bioactivity: Human interferon Alpha 2a (IFN-Alpha 2a), produced by leukocytes, is a member of the interferon family. IFN-alpha is primarily involved in the innate immune response against a broad range of viral infections. there are three acidic stable forms of IFN-alpha 2 (a,b,c) that signal through IFNAR2. IFN-alpha 2a shares 99.4% and 98.8% sequence identity with IFN-alpha 2b and 2c, respectively. IFN-alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is required for biological activity.
|Solubility (25°C)||It is not recommended to reconstitute to a concentration less than 100μg/ml.|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Paulo V S Dias, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Determination of recombinant Interferon-α2 in E. coli periplasmic extracts by reversed-phase high-performance liquid chromatography
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