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Recombinant Human IFN alpha2a(E.coli)

Cat. No. M20003
Recombinant Human IFN alpha2a(E.coli) Structure

Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A

Size Price Availability Quantity
10ug USD 83  USD83 In stock
50ug USD 150  USD150 In stock
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Quality Control & Documentation
  • Purity: >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Genus: Human
Expression system: E.coli
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Apparent molecular weight: 16 KDa, reduced conditions
Storage and stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.

Bioactivity: Human interferon Alpha 2a (IFN-Alpha 2a), produced by leukocytes, is a member of the interferon family. IFN-alpha is primarily involved in the innate immune response against a broad range of viral infections. there are three acidic stable forms of IFN-alpha 2 (a,b,c) that signal through IFNAR2. IFN-alpha 2a shares 99.4% and 98.8% sequence identity with IFN-alpha 2b and 2c, respectively. IFN-alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is required for biological activity.

Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Paulo V S Dias, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Determination of recombinant Interferon-α2 in E. coli periplasmic extracts by reversed-phase high-performance liquid chromatography

[2] Y Mohammed, et al. Biochemistry (Mosc). Expression of human interferon-α8 synthetic gene under P(BAD) promoter

[3] J Meng, et al. Cytotherapy. High-yield expression, purification and characterization of tumor-targeted IFN-alpha2a

[4] Zhen Yan, et al. Appl Biochem Biotechnol. Expression, refolding, and characterization of GFE peptide-fused human interferon-alpha2a in Escherichia coli

[5] E Baron, et al. Crit Rev Biotechnol. From cloning to a commercial realization: human alpha interferon

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Keywords: Recombinant Human IFN alpha2a(E.coli), Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A supplier, Recombinant Proteins, inhibitors, activators

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