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Recombinant Human IFN alpha2a(E.coli)

Cat. No. M20003
Recombinant Human IFN alpha2a(E.coli) Structure
Synonym:

Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A

Size Price Availability Quantity
10ug USD 66.4  USD83 In stock
50ug USD 120  USD150 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Genus: Human
Expression system: E.coli
Purity: >95% by reduced SDS-PAGE
Endotoxin: less than 0.1 ng/µg (1 EU/µg) by LAL test
Apparent molecular weight: 16 KDa, reduced conditions
Storage and stability: Lyophilized proteins should be stored at <-20°C, although stable at room temperature for up to 3 weeks. Reconstituted protein solutions can be stored at 4-7°C for 2-7 days. Recombinant sample aliquots are stable for 3 months at <-20°C.

Bioactivity: Human interferon Alpha 2a (IFN-Alpha 2a), produced by leukocytes, is a member of the interferon family. IFN-alpha is primarily involved in the innate immune response against a broad range of viral infections. there are three acidic stable forms of IFN-alpha 2 (a,b,c) that signal through IFNAR2. IFN-alpha 2a shares 99.4% and 98.8% sequence identity with IFN-alpha 2b and 2c, respectively. IFN-alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is required for biological activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 1 EU/µg
Solubility It is not recommended to reconstitute to a concentration less than 100μg/ml.
Storage at -20°C
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Keywords: Recombinant Human IFN alpha2a(E.coli), Interferon Alpha-2; IFN-Alpha-2; Interferon Alpha-A supplier, Cytokines, inhibitors

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