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Recombinant Human IFN-α 2b Protein (E. coli)

Cat. No. M54522
Recombinant Human IFN-α 2b Protein (E. coli) Structure
Synonym:

Interferon-Alpha 2b

Size Price Availability Quantity
10ug USD 80  USD80 In stock
50ug USD 145  USD145 In stock
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Quality Control & Documentation
  • Purity: >95%, Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

IFN-α 2b (Interferon-Alpha 2b) [Cys24-Glu188 (Lys46Arg)] produced by leukocytes is a member of Interferon family. IFN-alpha is mainly involved in innate immune response against a broad range of viral infections.

Measured by a cytotoxicity assay using TF-1 cells, the ED50 is < 0.05 ng/ml, corresponding to a specific activity of > 2.0 × 107 units/mg.


Accession: P01563

Endotoxin < 0.2 EU/µg

Apparent Molecular Weight: ~19.2 kDa, reducing conditions

Lyophilized after extensive dialysis against PBS.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

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Keywords: Recombinant Human IFN-α 2b Protein (E. coli), Interferon-Alpha 2b supplier, Recombinant Proteins, inhibitors, activators


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