Recombinant Human HGFR Protein is a glycosylation receptor tyrosine kinase, which plays a central role in epithelial morphogenesis and cancer development. HGFR is usually expressed by epithelial cells, and the expression of HGF is limited to mesenchymal cells. Under HGF stimulation, HGFR induces several biological responses, which together produce a program called invasive growth. Abnormal HGFR activation in cancer is associated with poor prognosis. Abnormally active HGFR triggers tumor growth, forms new blood vessels (angiogenesis), provides nutrition for the tumor, and cancer can spread to other organs (metastasis). In many types of human malignancies, including kidney cancer, liver cancer, stomach cancer, breast cancer, and brain cancer, HGFR is deregulated. HGFR mediates a complex procedure called invasive growth. The activation of HGFR triggers mitosis and morphogenesis.
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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