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Recombinant Human HGFR Protein is a glycosylation receptor tyrosine kinase, which plays a central role in epithelial morphogenesis and cancer development. HGFR is usually expressed by epithelial cells, and the expression of HGF is limited to mesenchymal cells. Under HGF stimulation, HGFR induces several biological responses, which together produce a program called invasive growth. Abnormal HGFR activation in cancer is associated with poor prognosis. Abnormally active HGFR triggers tumor growth, forms new blood vessels (angiogenesis), provides nutrition for the tumor, and cancer can spread to other organs (metastasis). In many types of human malignancies, including kidney cancer, liver cancer, stomach cancer, breast cancer, and brain cancer, HGFR is deregulated. HGFR mediates a complex procedure called invasive growth. The activation of HGFR triggers mitosis and morphogenesis.
Recombinant Human HGFR expressed the target gene encoding Glu25-Thr932 with a human IgG1 Fc tag at the C-terminus.
Accession: P08581
Apparent Molecular Weight: 170&100-130&45-50 KDa, reducing conditions
Endotoxin < 1 EU/µg
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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Products are for research use only. Not for human use. We do not sell to patients.
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