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Recombinant Human HGFR Protein (HEK293)

Cat. No. M9891
Recombinant Human HGFR Protein (HEK293) Structure
Size Price Availability Quantity
50ug USD 331.2  USD368 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.1EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human HGFR Protein is a glycosylation receptor tyrosine kinase, which plays a central role in epithelial morphogenesis and cancer development. HGFR is usually expressed by epithelial cells, and the expression of HGF is limited to mesenchymal cells. Under HGF stimulation, HGFR induces several biological responses, which together produce a program called invasive growth. Abnormal HGFR activation in cancer is associated with poor prognosis. Abnormally active HGFR triggers tumor growth, forms new blood vessels (angiogenesis), provides nutrition for the tumor, and cancer can spread to other organs (metastasis). In many types of human malignancies, including kidney cancer, liver cancer, stomach cancer, breast cancer, and brain cancer, HGFR is deregulated. HGFR mediates a complex procedure called invasive growth. The activation of HGFR triggers mitosis and morphogenesis.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.1EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




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