Hepatocyte growth factor/dispersion factor (HGF/SF) is a paracrine cell growth, motility and morphogenesis factor. It belongs to the peptidase S1 family and plasminogen subfamily, and contains 4 Kringle domains, 1 PAN domain and 1 peptidase S1 domain. HGF binds to proto-oncogenic C-Met receptor and regulates cell growth, motility and morphogenesis by activating tyrosine kinase signal cascade. HGF is secreted by mesenchymal cells and is a multifunctional cytokine mainly derived from more than skin cells. Its ability to stimulate mitosis, cell motility, and stromal invasion makes it a central player in angiogenesis, tumorigenesis, and tissue regeneration.
Measured by its ability to induce IL-11 secretion by Saos‑2 human osteosarcoma cells, the ED50 for this effect is 0.3-1.5 ng/ml.
Accession# : P14210
Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 500mM NaCl, pH 8.0.
| Solubility (25°C) | Dissolve the lyophilized protein in distilled water. It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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