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Recombinant Human HDAC8 Protein (GST Tag)

Cat. No. M45068

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human HDAC8 Protein (GST Tag) Structure
Synonym:

Histone deacetylase 8

Size Price Availability Quantity
100ug USD 875  USD875 In stock
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Quality Control & Documentation
  • Purity: > 88 %, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells.


Endotoxin < 1 EU/µg

Apparent Molecular Weight: 68 kDa, reducing conditions

Lyophilized from sterile 50mM Tris, 100mM NaCl, 0.5mM PMSF, 10% glycerol, pH 8.0

Chemical Information
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
References

[1] Jieying Wu, et al. Biol Chem. HDAC8 promotes daunorubicin resistance of human acute myeloid leukemia cells via regulation of IL-6 and IL-8

[2] Pu Zhang, et al. Clin Cancer Res. Targeting DNA Damage Repair Functions of Two Histone Deacetylases, HDAC8 and SIRT6, Sensitizes Acute Myeloid Leukemia to NAMPT Inhibition

[3] Jessica Piché, et al. Cell Cycle. The expanding phenotypes of cohesinopathies: one ring to rule them all!

[4] Martin Marek, et al. Methods Mol Biol. Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni

[5] Heehyoung Lee, et al. Mol Cell Biol. Histone deacetylase 8 safeguards the human ever-shorter telomeres 1B (hEST1B) protein from ubiquitin-mediated degradation

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Keywords: Recombinant Human HDAC8 Protein (GST Tag), Histone deacetylase 8 supplier, Cytokines and Growth Factors, inhibitors, activators

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