Free shipping on all orders over $ 500

Recombinant Human Granzyme B Protein (HEK293, C-His)

Cat. No. M45089
Recombinant Human Granzyme B Protein (HEK293, C-His) Structure
Synonym:

CGL-1; CSP-B; GZMB

Size Price Availability Quantity
50ug USD 900  USD900 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >97%, Endotoxin < 1 EU/µg
  • COA
  • MSDS
Biological Activity

Granzyme B is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Granzyme B (GZMB) protects the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.

The recombinant human Granzyme B consists of 240 amino acids and has a calculated molecular mass of 27.2 kDa. A DNA sequence encoding the proform of human Granzyme B (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.


Endotoxin < 1 EU/µg

Apparent Molecular Weight: 35-40 kDa, reducing conditions

Lyophilized from sterile PBS, pH 7.4.

Chemical Information
Form Lyophilized powder
Solubility (25°C) Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.
Storage Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Related Recombinant Proteins Products
Recombinant Human CXCL4/PF-4 Protein (Mammalian, C-6His)

Human CXCL4/PF-4 is expressed in megakaryocytes and stored in the alpha-granules of platelets. CXCL4/PF-4 is chemotactic for neutrophils, fibroblasts and monocytes and plays a critical role in inflammation and wound repair.

Recombinant Mouse/Rat TGF-beta 2 Protein (Mammalian)

Transforming growth factor beta 2 (TGF-β2) is a member of TGF-beta superfamily that shares a characteristic cysteine knot structure.

Recombinant Mouse FABP4 Protein (HEK293, C-His)

FABP4 is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid binding protein (FABP) family.

Recombinant Human IFN-α 2b Protein (E. coli)

IFN-α 2b (Interferon-Alpha 2b) [Cys24-Glu188 (Lys46Arg)] produced by leukocytes is a member of Interferon family. IFN-alpha is mainly involved in innate immune response against a broad range of viral infections.

Recombinant Rat IL-2 (Mammalian, C-6His)

Interleukin-2 (IL-2) is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.

  Catalog
Abmole Inhibitor Catalog




Keywords: Recombinant Human Granzyme B Protein (HEK293, C-His), CGL-1; CSP-B; GZMB supplier, Recombinant Proteins, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.