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Granzyme B is the most prominent member of the granzyme family of cell death-inducing serine proteases expressed in the granules of cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B results in the activation of effector caspases and mitochondrial depolarization through caspase-dependent and -independent pathways, and consequently induces rapid cell apoptosis. Granzyme B (GZMB) protects the host by lysing cells bearing on their surface 'nonself' antigens such as bacterial and viral infected-cells and tumor cells and accordingly plays an essential role in immunosurveillance.
The recombinant human Granzyme B consists of 240 amino acids and has a calculated molecular mass of 27.2 kDa. A DNA sequence encoding the proform of human Granzyme B (Met 1-Tyr 247) was expressed with a C-terminal polyhistidine tag.
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 35-40 kDa, reducing conditions
Lyophilized from sterile PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
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