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Recombinant Human GPNMB (HEK293, C-6His)

Cat. No. M21638

All AbMole products are for research use only, cannot be used for human consumption.

Recombinant Human GPNMB (HEK293, C-6His) Structure
Synonym:

Glycoprotein Non-Metastatic Melanoma Protein B

Size Price Availability Quantity
10ug USD 165  USD165 In stock
50ug USD 355  USD355 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
  • Purity: >95%, Endotoxin < 1 EU/μg
  • COA
  • MSDS
Biological Activity

Recombinant Human GPNMB (Glycoprotein Non-Metastatic Melanoma Protein B) is produced by Mammalian expression system and the target gene encoding Ala22-Pro486 is expressed with a 6His tag at the C-terminus. Osteoactivin is an intracellular glycoprotein belongs to the NMB/pMEL-17 family, which is asscociated with cell endosomal/lysomal compartments. Cells knowns to express Osteoactivin include fibroblast, osteoblasts, myeloid dendritic cell, melanocytes, plus fetal chondrocytes and stratum basale keratinocytes, macrophages/keratinocytes.

Chemical Information
Solubility (25°C) Reconstitute the lyophilized powder in distilled water to a concentration of 100μg/ml
Storage Stored at ≤ -20°C, stable for one year after receipt
References

[1] M Liguori, et al. Cell Mol Immunol. The soluble glycoprotein NMB (GPNMB) produced by macrophages induces cancer stemness and metastasis via CD44 and IL-33

[2] Matthew L Neal, et al. J Neuroinflammation. The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor

[3] Moses O Oyewumi, et al. Oncotarget. Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells

[4] Aifu Lin, et al. Nat Cell Biol. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

[5] Yu-Liang Wang, et al. Int J Clin Exp Pathol. Effects of GPNMB on proliferation and odontoblastic differentiation of human dental pulp cells

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Keywords: Recombinant Human GPNMB (HEK293, C-6His), Glycoprotein Non-Metastatic Melanoma Protein B supplier, Cytokines and Growth Factors, inhibitors, activators

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