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Recombinant Human Glial Cell Line-derived Neurotrophic Factor

Cat. No. M10344
Recombinant Human Glial Cell Line-derived Neurotrophic Factor Structure
Synonym:

rHuGDNF

Size Price Availability Quantity
10ug USD 270  USD300 In stock
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Quality Control
  • Current batch:
  • Purity >97%, Endotoxin < 0.1 EU/μg
  • COA
  • MSDS
Biological Activity

Glial cell-derived neurotrophic factor is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

The ED50 as determined by a cell proliferation assay using rat C6 cells is less than 0.1 ng/ml, corresponding to a specific activity of > 5.0 × 107 IU/mg.

We recommend briefly centrifuged this vial before opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C.

Source: Escherichia coli.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >97%, Endotoxin < 0.1 EU/μg
Solubility Water
Saline
PBS
Storage at -20°C
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Keywords: Recombinant Human Glial Cell Line-derived Neurotrophic Factor, rHuGDNF supplier, Cytokines, inhibitors

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