Species: Human
Expression system: Human Cells
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test measured less than 0.1 ng/µg (1eu /µg)
Molecular weight: 36.7KDa
Storage and stability: Freeze-dried protein should be stored at < -20℃, but stable at room temperature for 3 weeks. The recombinant protein solution can be stored at 4-7℃ for 2-7 days. The bisector of the recombinant sample was stable at < -20°C for 3 months.
Bioactivity: Galectin-9 is a cytoplasmic protein containing two galectin-domains. Galactin-9 is an S-type lectin that is overexpressed in Hodgkin's disease tissues. Galactosidine -9 binds galactoside and has a high affinity for Forssman five sugars. Galactin-9 plays a role in thymocyte-epithelial interactions, is relevant to thymus biology, and inhibits cell proliferation. Galectin-9, a ligand of HAVCR2/TIM3, induces the death of T-helper type 1 lymphocytes (Th1). In addition, Galectin-9 inhibits tumor cell metastasis by interfering with CD44, VCAM-1, Integrin α4β1 and other factors.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[5] Valerie R Wiersma, et al. Med Res Rev. Therapeutic potential of Galectin-9 in human disease
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