FGF acid, also known as ECGF, FGF-1 and HBGF-1, is a non-glycosylated heparin-binding growth factor expressed in brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide produced by a variety of cell types and stimulates cell proliferation in the mesoderm, ectoderm and endoderm. Its binding to heparan sulfate is a prerequisite for activation of the FGF receptor. Internalized FGF acidic migrates to the nucleus, where it is phosphorylated by nuclear PKC delta, exported to the cell membrane, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and pro-apoptotic signaling.
Recombinant Human FGF1/ECGF expressed the target gene encoding Ala2-Asp155.
Accession: P05230
Endotoxin < 1 EU/µg
Apparent Molecular Weight: 17 KDa, reducing conditions
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in distilled water up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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