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Recombinant Human FGF-8b Protein

Cat. No. M10003
Recombinant Human FGF-8b Protein Structure
Synonym:

Fibroblast Growth Factor-8b

Size Price Availability Quantity
20ug USD 162  USD180 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human FGF-8b Protein is a heparin-binding growth factor, which plays a core role in prenatal development, postnatal growth and regeneration of various tissues by promoting cell proliferation and other effect. FGF-8 (FGF-8b) belongs to the FGF family. Human and mouse FGF-8A and B are exactly the same, while human and mouse FGF-8E and F are 98% identical. FGF-8 mainly targets breast cancer cells and other cells that express FGF receptors. 

The recombinant human FGF-8b protein contains 431 amino acids and the predicted molecular weight is 49.3kd. 

Determined by the dose-dependent stimulation effect of thymine expressing FGF receptor in BaF3 cells, ED50 value should be ≤1 ng/ml, combined with its specific activity ≥1×106 IU/mg. 

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.01EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
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Keywords: Recombinant Human FGF-8b Protein, Fibroblast Growth Factor-8b supplier, Cytokines, inhibitors

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