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Recombinant Human Fetuin A Protein

Cat. No. M10010
Recombinant Human Fetuin A Protein Structure
Synonym:

Human AHSG

Size Price Availability Quantity
100ug USD 531  USD590 In stock
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Quality Control
  • Current batch:
  • Purity ≥95%, Endotoxin ≤0.01EU/ug
  • COA
  • MSDS
Biological Activity

Recombinant Human Fetuin A Protein is a major plasma protein and a member of the cystatin superfamily of protease inhibitors. Human Fetuin A is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. It is a negative acute-phase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection. Human Fetuin A inhibits both insulin receptor autophosphorylation and undesirable calcification . It also can act as a natural antagonist against specific TGF-β and BMP signaling proteins. 

Expression host is Human HEK293 cells

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity ≥95%, Endotoxin ≤0.01EU/ug
Solubility Water
Saline
PBS
Storage 2-8°C, dry, sealed
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Human Fetuin A Protein, Human AHSG supplier, Cytokines, inhibitors

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