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Recombinant Human EGF (E. coli)

Cat. No. M10354
Recombinant Human EGF (E. coli) Structure
Synonym:

rhEGF

Size Price Availability Quantity
100ug USD 126  USD140 In stock
500ug USD 234  USD260 In stock
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Quality Control
  • Current batch:
  • Purity >95%, Endotoxin < 0.1 ng/µg (1 EU/μg)
  • COA
  • MSDS
Biological Activity

Epidermal Growth Factor (EGF) is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. Recombinant human EGF is a 6.2 kDa globular protein containing 53 amino acid residues including 3 intramolecular disulfide-bonds. Recombinant human Epidermal Growth Factor (rhEGF) produced in E. coli is a non-glycosylated polypeptide chain of 54 amino acids. 

ED50 <0.6ng/ml, measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblasts in serum-free medium and CellTiter-Glo cell viability assay, corresponding to a specific activity of >1.7 x 106 units/mg.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95%, Endotoxin < 0.1 ng/µg (1 EU/μg)
Solubility Reconstituted in ddH2O at 100 μg/ml
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Recombinant Human EGF (E. coli), rhEGF supplier, Cytokines, inhibitors

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