Purity: sdS-PAGE determination was >90%
Protein construction: The DNA sequence encoding human CYP3A4 (Gly26-Ala503) was fused with His marker
Predicted molecular weight: 52.98 kDa
Stability and storage: use manual defrosting refrigerator to avoid repeated freeze-thaw cycles.
Store at 2-8 °C for one week.
Store at -20 to -80°C for 12 months from date of receipt.
CYP3A4 is an important member of the cytochrome P45 enzyme superfamily, with 33 alleles. Human cytochrome P45 3A4 (CYP3A4) is an important drug metabolism enzyme involved in many drug-drug and food-drug interactions. Systemic inflammation is associated with inhibition of CYP3A4 activity.
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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