All AbMole products are for research use only, cannot be used for human consumption.
Species: Human/Cynomolgus
Expression system: Mammalian
Molecular weight: 16.7 KDa
Purity: > 95% as determined by reduced SDS-PAGE
Endotoxin: LAL test less than 0.1 ng/µg (1 EU/µg)
Storage and stability: The freeze-dried protein should be stored at ≤-20℃ and stored stably for one year after receiving. The recombinant protein solution can be stored at 2-8℃ for 2-7 days. The recombinant samples were stable for 3 months at ≤-20°C.
Bioactivity: t cell-specific surface glycoprotein CD28(CD28) is a single-channel membrane protein containing an IGg-like EV-like (immunoglobulin-like) domain. It belongs to the immunoglobulin (Ig) superfamily. CD28 is a molecule expressed on T cells that provides a costimulatory signal needed for T cell activation. CD28 co-stimulation is necessary for CD4-positive t cell proliferation and survival, interleukin-2 production, and T-helper type 2 development. Human thymus retroregulatory T cells require CD28 co-stimulation in order to expand and maintain effective inhibitory function in vivo. Apoptosis plays a key role in age-related decline in CD28 expression and immunosenescence. CD28 is a receptor for CD80 (B7.1) and CD86 (B7.2). CD80 is upregulated in antigen-presenting cells (APCs) when activated by toll-like receptor ligands. The expression of CD86 on antigen presenting cells is constitutive. CD28 is the only B7 receptor that is constitutively expressed on naive T cells.
| Solubility (25°C) | It is not recommended to reconstitute to a concentration less than 100μg/ml. |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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