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Recombinant Human CXCL16 (Val52-Lys190) (E.coli)

Cat. No. M21344
Recombinant Human CXCL16 (Val52-Lys190) (E.coli) Structure
Synonym:

C-X-C motif chemokine 16

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50ug USD 270  USD270 In stock
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Quality Control & Documentation
  • Purity: >90% , Endotoxin <1 EU/μg
  • COA
  • MSDS
Biological Activity

Genus: Human
Expression system: E.coli
Purity: >90% by SDS-PAGE
Predicted molecular weight: 17.14 kDa
Storage and Stability: Use a manually thawed refrigerator to avoid repeated freeze-thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for 12 months from date of receipt.


Bioactivity: Acts as a scavenger receptor for macrophages and binds specifically to OxLDL (oxidized low-density lipoprotein), suggesting its possible involvement in pathophysiology such as atherosclerosis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.





Chemical Information
Solubility (25°C) It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yi Gong, et al. Microbes Infect. Prognostic and pathogenic role of CXC motif ligand 16 in sepsis

[2] Sheng Zuo, et al. Can Respir J. CXCL16 Induces the Progression of Pulmonary Fibrosis through Promoting the Phosphorylation of STAT3

[3] Weitao Zhang, et al. Am J Transl Res. CXCL16 is activated by p-JNK and is involved in H2O2-induced HK-2 cell injury via p-ERK signaling

[4] Kirsten Hattermann, et al. Cell Commun Signal. "Inverse signaling" of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

[5] Yu Huang, et al. Fen Zi Xi Bao Sheng Wu Xue Bao. [Chemokine CXCL16 induces proliferation and invasion of human first-trimester cytotrophoblasts in autocrine manner]

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Keywords: Recombinant Human CXCL16 (Val52-Lys190) (E.coli), C-X-C motif chemokine 16 supplier, Recombinant Proteins, inhibitors, activators


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